«Pendant des siècles, la Médecine s’est préoccupée de soigner. Aujourd’hui elle s'est donnée comme but de prévenir plutôt que de guérir.»
Pr Jean Dausset, Prix Nobel de Médecine, 1980
La Fondation Jean Dausset - Centre d’Etude du Polymorphisme Humain participe aux efforts nationaux et internationaux de recherche pour mieux déterminer le rôle du polymorphisme génétique chez l’Homme, tout particulièrement dans les maladies complexes, pour mieux les comprendre, les diagnostiquer et participer au développement d’une médecine personnalisée.

CEPH Publications by year


Major Publications2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007

Geoffroy V, Stoetzel C, Scheidecker S, Schaefer E, Perrault I, Bär S, Kröll A, Delbarre M, Antin M, Leuvrey AS, Henry C, Blanché H, Decker E, Kloth K, Klaus G, Mache C, Martin-Coignard D, McGinn S, Boland A, Deleuze JF, Friant S, Saunier S, Rozet JM, Bergmann C, Dollfus H, Muller J. Whole genome sequencing in patients with ciliopathies uncovers a novel recurrent tandem duplication in IFT140. Hum Mutat. 2018 Apr 24. doi: 10.1002/humu.23539. [Epub ahead of print] PMID:29688594

Bonnet E, Moutet ML, Baulard C, Bacq-Daian D, Sandron F, Mesrob L, Fin B, Delépine M, Palomares MA, Jubin C,Blanché H, Meyer V, Boland A, Olaso R, Deleuze JF. Performance comparison of three DNA extraction kits on human whole-exome data from formalin-fixed paraffin-embedded normal and tumor samples. PLoS One. 2018 Apr 5;13(4):e0195471. doi: 10.1371/journal.pone.0195471. eCollection 2018. PMID:29621323

Flachsbart F, Dose J, Gentschew L, Geismann C, Caliebe A, Knecht C, Nygaard M, Badarinarayan N, ElSharawy A, May S, Luzius A, Torres GG, Jentzsch M, Forster M, H√§sler R, Pallauf K, Lieb W, Derbois C, Galan P, Drichel D, Arlt A, Till A, Krause-Kyora B, Rimbach G, Blanché H, Deleuze JF, Christiansen L, Christensen K, Nothnagel M, Rosenstiel P, Schreiber S, Franke A, Sebens S, Nebel A. Publisher Correction: Identification and characterization of two functional variants in the human longevity gene FOXO3. Nat Commun. 2018 Jan 17;9(1):320. doi: 10.1038/s41467-018-02842-8. PMID:29339726

Mauger F, Kernaleguen M, Lallemand C, Kristensen VN, Deleuze JF, Tost J. Enrichment of methylated molecules using Enhanced-ice-co-amplification at lower denaturation temperature-PCR (E-ice-COLD-PCR) for the sensitive detection of disease-related hypermethylation. Epigenomics. 2018 Apr 26. doi: 10.2217/epi-2017-0166. [Epub ahead of print] PMID:29697281

Kernaleguen M, Daviaud C, Shen Y, Bonnet E, Renault V, Deleuze JF, Mauger F, Tost J. Whole-Genome Bisulfite Sequencing for the Analysis of Genome-Wide DNA Methylation and Hydroxymethylation Patterns at Single-Nucleotide Resolution Methods Mol Biol. 2018;1767:311-349. doi: 10.1007/978-1-4939-7774-1_18. PMID: 29524144

Stoeklé HC, Charlier P,Hervé C, Deleuze JF, Vogt G. Artificial intelligence in internal medicine: Between science and pseudoscience. Eur J Intern Med. 2018 May;51:e33-e34. doi: 10.1016/j.ejim.2018.01.027. Epub 2018 Feb 7. PMID: 29428496

How-Kit A, Daunay A, Buhard O, Meiller C, Sahbatou M, Collura A, Duval A, Deleuze JF. Major improvement in the detection of microsatellite instability in colorectal cancer using HSP110 T17 E-ice-COLD-PCR. Hum Mutat. 2018 Mar;39(3):441-453. doi: 10.1002/humu.23379. Epub 2017 Dec 26. PMID:29227006

Daviaud C, Renault V, Mauger F, Deleuze JF, Tost J. Whole-Genome Bisulfite Sequencing Using the Ovation Ultralow Methyl-Seq Protocol. Methods Mol Biol. 2018;1708:83-104. doi: 10.1007/978-1-4939-7481-8_5. PMID:29224140

Khan W, Saripella GV, Ludwig T, Cuppens T, Thibord F; FREX consortium, Génin E, Deleuze JF, Tr√©gou√ęt DA; GENMED Consorum MACARON: A python framework to identify and re-annotate multi-base affected codons in whole genome/exome sequence data Bioinformatics. 2018 May 3. doi: 10.1093/bioinformatics/bty382. [Epub ahead of print]

Donate and help
our research !
15 euros 30 euros
60 euros 90 euros
Other amount